A specific association between facial disgust recognition and estradiol levels in naturally cycling women.

Sunjeev K Kamboj,Kathleen M Krol,H Valerie Curran,Marina A Pavlova

doi:10.1371/journal.pone.0122311

Abstract

Subtle changes in social cognition are associated with naturalistic fluctuations in estrogens and progesterone over the course of the menstrual cycle. Using a dynamic emotion recognition task we aimed to provide a comprehensive description of the association between ovarian hormone levels and emotion recognition performance using a variety of performance metrics. Naturally cycling, psychiatrically healthy women attended a single experimental session during a follicular (days 7–13; n = 16), early luteal (days 15–19; n = 14) or late luteal phase (days 22–27; n = 14) of their menstrual cycle. Correct responses and reaction times to dynamic facial expressions were recorded and a two-high threshold analysis was used to assess discrimination and response bias. Salivary progesterone and estradiol were assayed and subjective measures of premenstrual symptoms, anxiety and positive and negative affect assessed. There was no interaction between cycle phase (follicular, early luteal, late luteal) and facial expression (sad, happy, fearful, angry, neutral and disgusted) on any of the recognition performance metrics. However, across the sample as a whole, progesterone levels were positively correlated with reaction times to a variety of facial expressions (anger, happiness, sadness and neutral expressions). In contrast, estradiol levels were specifically correlated with disgust processing on three performance indices (correct responses, response bias and discrimination). Premenstrual symptoms, anxiety and positive and negative affect were not associated with emotion recognition indices or hormone levels. The study highlights the role of naturalistic variations in ovarian hormone levels in modulating emotion recognition. In particular, progesterone seems to have a general slowing effect on facial expression processing. Our findings also provide the first behavioural evidence of a specific role for estrogens in the processing of disgust in humans.

Highlights

IntroductionThe capacity for understanding intentional mental states in other people (i.e. their beliefs, desires and intentions) is a cornerstone of co-operation, intimacy and general adaptive interpersonal functioning
The capacity for understanding intentional mental states in other people is a cornerstone of co-operation, intimacy and general adaptive interpersonal functioning
Posthoc analysis showed that follicular phase progesterone levels were significantly lower than the late luteal phase (p = 0.002).There was no difference across cycle phases in estradiol levels (F2,43 = 0.123, p>0.5)

Summary

Introduction

The capacity for understanding intentional mental states in other people (i.e. their beliefs, desires and intentions) is a cornerstone of co-operation, intimacy and general adaptive interpersonal functioning. A critical component of this capability involves decoding facial expressions of emotion in others, an ability which is formed early in human development and is exquisitely honed by adolescence, when decoding of subtle interpersonal cues becomes essential to adaptive functioning in communities Derangement of this capacity for mentalizing is a central feature of psychopathology [1] and may arise from adverse developmental experiences [2]. Changes in emotion recognition ability may reflect the formation and expression of cognitive-emotional biases such as those seen in anxiety and depression [8] Changes in these abilities in response to fluctuations in ovarian hormone levels may inform our understanding of these disorders, and their differing prevalence in men and women, as well as the onset of sex-specific disorders, such as Premenstrual Dysphoric Disorder (PMDD)

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