Abstract
To evaluate the possibility of urofollitropin preconditing to improve the sperm quality of infertility patients in ICSI treatment cycle in male patients who were diagnosed with moderate to severe oligospermia and asthenospermia, as well as the effect of treatment on fertilization rate and embryo quality. Prospective clinical controlled trial. By analyzing the data of the experimental group, which 24 patients were intramuscularly injected uFSH(urofollitropin) 150U every three days before the ICSI period for 12 consecutive weeks, whilst other 8 patients didn't injected as the blank control group and the ratio was 3 to 1, we compared the 2PN fertilization rate, the available embryo rate, the high-quality embryo rate and the blastocyst formation rate between the experimental group and the blank control group. There was no differences in the basic conditions inside the experimental group and the blank control group, such as the age of the male and female. The 2PN fertilization rate between the two groups was83.47% vs 81.69%, and the available embryo rate and blastocyst formation rate were 66.83 % vs 74.40 %, 54.95 % vs 67.74%, respectively . ontinuous use of uFSH 150U Q3D for 12 weeks before ICSI entry in patients with moderate to severe oligospermia and asthenospermia did not improve or increase the subsequent ICSI oosphere fertilization rate and embryo quality.Tabled 1Experimental groupThe blank groupPThe number of cases248The man age33.96 ± 1.16 (31.56, 36.35)31.75 ± 1.88 (27.31, 36.19)0.404The man BMI23.16 ± 0.53 (22.05, 24.26)25.42 ± 1.14 (22.72, 28.13)0.113Woman's age31.08 ± 0.87 (29.27, 32.89)30.25 ± 1.42 (26.88, 33.62)0.454The woman AMH3.30 ± 0.32 (2.64, 3.96)3.28 ± 0.45 (2.22, 4.32)0.949E2 on HCG day3537.00 ± 464.35 (2576.41, 4497.59)2903.13 ± 249.91 (2312.19, 3494.06)0.815Total Gn of the woman1868.75 ± 78.87 (1705.59, 2031.91)1906.25 ± 103.70 (1661.04, 2151.46)0.949A number of oospheres14.13 ± 1.72 (10.58, 17.67)10.63 ± 0.73 (8.90, 12.35)0.3342 pn fertilization rate(%)83.47(202/242)81.69 (58/71)0.725Available embryo rate(%)66.83 (135/202)74.14 (43/58)0.291Blastocyst formation rate(%)54.95 (50/91)67.74 (21/31)0.212 Open table in a new tab
Published Version
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