Abstract
Over the past decade, DNA has demonstrated remarkable potential in fabrication of molecular logic and arithmetic systems. In this work, a simple DNA-based system mimicking a full-subtractor that handles three inputs including one minuend and two subtrahends for eight input/output conditions is successfully designed. The whole system is established by one gate molecule and three input sequences, all made of single-stranded DNA sequences.
Highlights
Over the past decade, DNA has demonstrated remarkable potential in fabrication of molecular logic and arithmetic systems
In 1994, Adleman introduced a DNA-based biocomputing system for solving famous mathematic traveling salesman problems[4]. This led to additional explorations and experiments demonstrating that DNA sequences can serve as elementary computing devices such as half-adders[5,6,7,8], half-subtractors[9], full-adders[10], and full-subtractors[11]
This study presents a simple and elegant design of a full-subtractor using four single-stranded DNA molecules whereas an electronic full-subtractor in silico would require combinational circuits to perform subtraction
Summary
This study presents a simple and elegant design of a full-subtractor using four single-stranded DNA molecules whereas an electronic full-subtractor in silico would require combinational circuits to perform subtraction. The proposed DNA-based logic operations rely on the interactions among the four DNA strands to switch the gate molecule between hairpin and linear forms and to manipulate the duplex formation of the input strands. These controllable conditions determine the on/off patterns of the fluorescence signals, which correspond to the values in the Boolean truth tables of a full subtractor. The compactness of the proposed design makes it a promising foundation for future applications and integrations with other DNA-based computing devices, there is a long road ahead toward integrating the developed molecular systems for practical functions and competition with silicon-based technology. It is possible to adopt the design concept demonstrated along with other arrangement to blueprint new systems for medicinal usage
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