Abstract
A simple synthesis of stable phosphorus ylides from reaction between triphenylphosphine and acetylenic esters in the presence of CH-acid compounds
Highlights
The synthesis of phosphorus ylides is important in organic chemistry because of their applications in the synthesis of organic products,[1] especially the synthesis of naturally-occurring products with potentially useful biological and pharmacological properties.[2]
We report here an efficient synthetic route for the generation of stable phosphoranes bearing cyano groups via the reaction of triphenylphosphine with dialkyl acetylenedicarboxylates (1) in the presence of ISSN 1551-7012
Strong CH-acids such as malononitrile or ethyl cyanoacetate (2), which leads to the corresponding stable phosphorus ylides (3) in excellent yields (Scheme 1)
Summary
The synthesis of phosphorus ylides is important in organic chemistry because of their applications in the synthesis of organic products,[1] especially the synthesis of naturally-occurring products with potentially useful biological and pharmacological properties.[2].
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