Abstract
A simple synthesis of stable phosphorus ylides from reaction between triphenylphosphine and acetylenic esters in the presence of CH-acid compounds
Highlights
The synthesis of phosphorus ylides is important in organic chemistry because of their applications in the synthesis of organic products,[1] especially the synthesis of naturally-occurring products with potentially useful biological and pharmacological properties.[2]
We report here an efficient synthetic route for the generation of stable phosphoranes bearing cyano groups via the reaction of triphenylphosphine with dialkyl acetylenedicarboxylates (1) in the presence of ISSN 1551-7012
Strong CH-acids such as malononitrile or ethyl cyanoacetate (2), which leads to the corresponding stable phosphorus ylides (3) in excellent yields (Scheme 1)
Summary
The synthesis of phosphorus ylides is important in organic chemistry because of their applications in the synthesis of organic products,[1] especially the synthesis of naturally-occurring products with potentially useful biological and pharmacological properties.[2].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
