Abstract
A new procedure has been developed for the synthesis of 1-aminophosphonic acids. Diethyl phosphonates are converted to hydroxyiminophosphonates when treated with hydroxylamine hydrochloride. Reduction of hydroxyiminophosphonates with NaBH 4 in MeOH in the presence of MoO 3 or NiCl 2 and hydrolysis of 1- aminophosphonates gave 1-aminophosphonic acids in good yield.
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