Abstract
Rats chronically prepared with single, bipolar electrodes in caudal midbrain central gray matter can be used in successive weeks to demonstrate to laboratory course students: sensory evoked potentials in anesthetized and unanesthetized preparations; self-stimulation and/or escape; and stimulationproduced analgesia to peripheral pain. The preparation and procedures are simple, and accuracy in electrode placement is enhanced by the proximity of this structure to stereotaxic zero. Using the same animal repetitively minimizes time spent in surgical preparation and post-surgical recovery. The central gray matter is a relatively unexplored region, and studying it can lead to original observations.
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