Abstract
A spectrophotometric method based on the use of diazotization and coupling reaction was developed for the determination of metoclopramide hydrochloride (METH) by reacting a nitrogenous drug complex (D-METH) with reagent 4-chlororesorcinol (4-CRS). The alkaline dye gives a stable azoic red dye in the aqueous media, which gave the highest absorption at the wavelength of 527 nm and the limits of Beer's law had a linear relationship located within concentrations of 1-15 μg/ml and with a molar absorption coefficient of 2.53 × 104 L/mol. cm. Sandell's significance was 0.0140 μg/cm, while the LOD and LOQ values were 0.034 μg/ml and 0.114 μg/ml respectively. The proposed method has been successfully applied in the determination of metoclopramide hydrochloride in its pharmaceutical preparations in the form of tablets and injections.
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