Abstract
We developed an experimental setup for selective infrared (IR) stimulation of an isolated porcine vagus nerve. The system consists of an infrared IR diode (IR diode), providing an optical power of 6.5 W at λ = 1937 nm, high-quality fibre optic multimode patch cables, an optical pulse shaper, and a custom made experimental chamber.The system allows researchers to vary: the radiant exposure from 0 to 2.3 Jcm−2, vertical displacement of the IR aperture, nominal pulse duration that could be set at 250, 500, and 800 μs, and frequency of IR pulses between 15 and 50 Hz, enabling the assessment of the relationship between different patterns of IR pulses and the elicited nerve response (NR). The main contribution resulting from the study is an optical pulse shaper, which generates IR pulses with a rise-time of approximately 100 ns, and facilitates an appropriate coupling efficiency via a Grin Lens Fibre Coupler/Fibre Optic Positioner. Another novelty is the 3D positioning device of the experimental chamber, which enables the ex-vivo assessment of spatial and fibre-type selectivity.
Published Version
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