Abstract
In our hands, methods purporting to detect 35 μg and 400 μg/1. quantities of bufotenin in schizophrenic urine cannot be confirmed. Criticism was offered of these methods which would tend to make suspect any conclusions drawn from their use. A chemical method which claimed to detect 50 μg of bufotenin per 1. of normal urine was shown to be erroneous in its conclusions. A method was presented which is sensitive to at least 1 μg of bufotenin per 1. of urine. By this method, in not one of five normals nor in any of 21 schizophrenics could any bufotenin be detected. These results indicate that bufotenin cannot be measurably present in urine of schizophrenic patients, nor do they support a hypothesis involving bufotenin in the etiology of schizophrenia.
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