Abstract
The distribution of chlorpromazine and its phenolic and non-phenolic metabolites was studied in the urine of schizophrenic patients by gas—liquid chromatography on OV-17, using a flame ionization detector. Unconjugated phenolic metabolites, 7-hydroxychlorpromazine and 7-hydroxydemethylchlorpromazine in the crude extract were determined as their trimethylsilyl derivatives using N-trimethylsilylimidazole in the presence of pyridine. Trimethylsilyl 7-hydroxychlorpromazine and trimethylsilyl 7-hydroxydemethylchlorpromazine have greatly improved chromatographic properties and enable the investigator both to separate and identify the 7-hydroxy derivatives easily by gas—liquid chromatography. In addition to the phenolic metabolites, the major non-phenolic derivatives identified in urine include chlorpromazine N-oxide, chlorpromazine, demethylchlorpromazine, chlorpromazine sulfoxide and demethylchlorpromazine sulfoxide.
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