Abstract
A recent communication (ANGERER et al., 1973) has reviewed the requirement for the sensitive and reliable estimation of volatile organic vapors in blood. Threshold Limit Values for the chronic exposure of industrial workers have been established for a variety of hazardous volatile organic substances (AMERICAN CONFERENCE OF GOVERNMENTAL INDUSTRIAL HYGIENISTS, 1971). Many of these may be detected in the circulating blood and the results provide evidence of exposure and, in some cases, the extent of intoxication. Thus, there is a continuing need for sensitive micromethods for the quantitative analysis of low concentrations of volatile organic compounds in blood and other biological fluids. Such methods tan then be utilized for the monitoring of exposed human populations by the acceptable and convenient linger puncture sampling technique. Micromethods are also of value in determining blood level curves from small animals which have a limited total blood volume.
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