Abstract
A gas chromatographic method for the determination of propranolol in plasma has been developed. After solvent extraction, a difluorobutyrate derivative is formed, which is measured by an electron capture detector. The quantification is controlled by using an internal standard, pronethalol, which is added to all samples. The electron capture detector response was linear between 5 and 80 ng/ml. No interference from common cardiovascular drugs was found. Concentrations of propranolol in the plasma determined by this method were directly related to the administered dose of the drug.
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