Abstract
In this paper, graphene (Gr)/Co3O4 nanocomposite was synthesized and utilized for the development of a novel electrochemical sensor to detect tramadol. Tramadol determination was examined by linear sweep voltammetry, differential pulse voltammetry, cyclic voltammetry, and chronoamperometry on Gr/Co3O4 nanocomposite-modified screen-printed electrode (Gr/Co3O4/SPE) in phosphate-buffered saline (PBS). Under the optimized condition, the detection limit of tramadol is 0.03 μM (S/N = 3) in the linear ranges of 0.1–500.0 μM. Furthermore, Gr/Co3O4/SPE was satisfactorily utilized to detect tramadol in tramadol tablet and urine specimens.
Highlights
Tramadol is a synthetic analog of codeine that acts as a central analgesic
Tramadol determination was examined by linear sweep voltammetry, differential pulse voltammetry, cyclic voltammetry, and chronoamperometry on Gr/Co3O4 nanocomposite-modified screen-printed electrode (Gr/Co3O4/SPE) in phosphate-buffered saline (PBS)
Electrode Modified With Graphene/Co3O4 Nanocomposite for Electrochemical Detection of Tramadol
Summary
Reviewed by: Fei Peng, Harvard Medical School, United States Mingzai Wu, Anhui University, China. Mohammad Reza Aflatoonian 1,2, Somayeh Tajik 3*, Behnaz Aflatoonian 1, Hadi Beitollahi 4, Kaiqiang Zhang 5, Quyet Van Le 6*, Joo Hwan Cha 7, Ho Won Jang 5, Mohammadreza Shokouhimehr 5* and Wanxi Peng 8,9*. Graphene (Gr)/Co3O4 nanocomposite was synthesized and utilized for the development of a novel electrochemical sensor to detect tramadol. Tramadol determination was examined by linear sweep voltammetry, differential pulse voltammetry, cyclic voltammetry, and chronoamperometry on Gr/Co3O4 nanocomposite-modified screen-printed electrode (Gr/Co3O4/SPE) in phosphate-buffered saline (PBS). The detection limit of tramadol is 0.03 μM (S/N = 3) in the linear ranges of 0.1–500.0 μM. Gr/Co3O4/SPE was satisfactorily utilized to detect tramadol in tramadol tablet and urine specimens. Electrode Modified With Graphene/Co3O4 Nanocomposite for Electrochemical Detection of Tramadol.
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