A Scarce Presentation of &amp;lt;i&amp;gt;Mycobacterium tuberculosis&amp;lt;/i&amp;gt;, Case Report

Mahsa Alinaghian,Hasan Salehi,Mohammad Mehdi Salehi

doi:10.4236/aid.2018.81003

A Scarce Presentation of &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt;, Case Report

Mahsa Alinaghian, Hasan Salehi + Show 1 more

Open Access

https://doi.org/10.4236/aid.2018.81003

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Abstract

Here, we report a case of 24-year-old female who experienced fever, weight loss, and headache by the termination of her pregnancy after 24 weeks. She was admitted due to multiple generalized tonic clonic (GTC) seizures and loss of consciousness. Her lab data and histological findings were insignificant as well as negative mycobacterium culture. Her brain MRI detected multiple enhanced brain lesions on T2 weighted images. Overall, she went under empiric anti-TB treatment for a year and had a complete recovery. To our knowledge, this is the first reported case of brain tuberculoma with negative histological findings and brain tissue culture who responded to an empiric anti-TB regimen.

Highlights

Tuberculosis (TB) infection is a global trending concern, which is responsible for higher mortality rate among middle-aged women [1] [2]
Her brain MRI detected multiple enhanced brain lesions on T2 weighted images. She went under empiric anti-TB treatment for a year and had a complete recovery. This is the first reported case of brain tuberculoma with negative histological findings and brain tissue culture who responded to an empiric anti-TB regimen
It was claimed that fever and seizure were the most common symptoms while weight loss might be hidden due to weight gain during pregnancy [3]

Summary

Introduction

Tuberculosis (TB) infection is a global trending concern, which is responsible for higher mortality rate among middle-aged women [1] [2]. One third of mortality among reported active TB cases in 2013 were women in reproductive age. Similar to HIV patients with immune suppression [2] [9] [10], pregnancy and post-partum state adversely affects women’s immune system that exposes them to higher risk of quiescent infections reactivation. Despite the fact that CNS TB infection induces further mortality and neurological sequela, around 1% of all TB reported cases involve the nervous system [7] [11]. We propound an odd display of CNS tuberculoma in a young post-partum female who had been referred to us with seizure and altered mental status

Case Presentation

Findings

Discussion

Conclusion