Abstract
Immunometabolism Ketogenesis is a fundamental biochemical process occurring mainly in liver mitochondria. This pathway provides energy to vital organs when access to glucose is limited for prolonged periods, such as during fasting. Lipolysis-derived fatty acids normally initiate this process via the transcription factor PPAR-α. Misto et al. found that fasting stimulates mast cells to release histamine, which stimulates the biosynthesis of the high-affinity PPAR-α agonist oleoylethanolamide via G protein–coupled H1 receptors. Thus, mast cells, recognized for their role in allergy and anaphylaxis, unexpectedly take part in the regulation of a major metabolic pathway. Future studies will be needed to uncover the underlying mechanisms of this process and understand how it may contribute to metabolic dysfunction. Cell Metab. 10.1016/j.cmet.2018.09.014 (2018).
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