Abstract

In conclusion, rapid advances in our understanding of the molecular basis of T cell recognition have revealed a number of approaches for immune intervention in autoimmune disease. Each procedure has been tried and tested in experimental models. Characterization of T cell recognition in human autoimmune disease is a step behind. However, their success in experimental models indicates that MHC-blocking peptides will find use both in identification of restriction elements for disease and in the prevention and treatment of human autoimmune conditions.

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