Abstract
The Labisia pumila (LP) is a traditional plant that is locally known as Kacip Fatimah, Selusuh Fatimah, or Pokok Ringgang by the Malaysian indigenous people. It is believed to facilitate their childbirth, treating their postchild birth and menstrual irregularities. The water extract of LP has shown to contain bioactive compounds such as flavonoids, ascorbic acid, β-carotene, anthocyanin, and phenolic acid, which contribute extensive antioxidant, anti-inflammatory, antimicrobial, and antifungal. The LP ethanolic extract exhibits significant estrogenic effects on human endomentrial adenocarcinoma cell in estrogen-free basal medium and promoting an increase in secretion of alkaline phosphate. Water based has been used for many generations, and studies had reported that it could displace in binding the antibodies and increase the estradiol production making it similar to esterone and estradiol hormone. LP extract poses a potential and beneficial aspect in medical and cosmeceutical applications. This is mainly due to its phytoestrogen properties of the LP. However, there is a specific functionality in the application of LP extract, due to specific functional group in phytoconstituent of LP. Apart from that, the extraction solvent is important in preparing the LP extract as it poses some significant and mild side effects towards consuming the LP extracts. The current situation of women reproductive disease such as postmenopausal syndrome and polycystic ovary syndrome is increasing. Thus, it is important to find ways in alternative treatment for women reproductive disease that is less costly and low side effects. In conclusion, these studies proven that LP has the potential to be an alternative way in treating female reproductive related diseases such as in postmenopausal and polysystic ovarian syndrome women.
Highlights
The Labisia pumila (LP) is a traditional plant that is commonly known as Kacip Fatimah, Selusuh Fatimah, and Pokok Ringgang by the indigenous people
Studies had reported that consumption of LP water extract protects the bone from estrogen deficiency by regulating the receptor activator of nuclear factor kappa-B ligand (RANKL), Osteoprotegerin, and bone morphogenetic protien-2 of gene expression which can lead to osteoporosis (S N [13])
The LP extract poses potential and beneficial aspects in both medical and cosmeceutical applications. This is mainly due to its phytoestrogen properties of the LP
Summary
The Labisia pumila (LP) is a traditional plant that is commonly known as Kacip Fatimah, Selusuh Fatimah, and Pokok Ringgang by the indigenous people. The growing interests in LP on phytoestrogen effects have shown potential benefits on the women reproductive performance. This phytoestrogen in LP acted as a pair of hydroxyl group and a phenolic ring which function to bind estrogen receptors [8]. The estrogen deficiency has become a major problem among women It is the cause of postmenopausal bone loss and contributes to the age-related bone loss. Studies had shown that the estrogen deficiency is associated with the increase in production of tumor necrosis alpha factor by bone marrow T cells which augments receptor activator of nuclear factor kappa-B ligand (RANKL) induced by osteoclastogenesis [12]. The objective of this review article is to demonstrate the inclusive studies on the therapeutic effects of LP on female reproductive related disorder and supported the use of LP as herbal medicine
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