Abstract
Viral infectious diseases pose a serious threat to animal husbandry, especially in the pig industry. With the rapid, continuous variation of viruses, a series of therapeutic measures, including vaccines, have quickly lost their efficacy, leading to great losses for animal husbandry. Therefore, it is urgent to find new drugs with more stable and effective antiviral activity. Recently, it has been reported that antimicrobial peptides (AMPs) have great potential for development and application in animal husbandry because of their significant antibacterial and antiviral activity, and the antiviral ability of AMPs has become a research hotspot. This article aims to review the research situation of AMPs used to combat viruses in swine production of animal husbandry, clarify the mechanism of action of AMPs on viruses and raise some questions, and explore the future potential of AMPs in animal husbandry.
Highlights
Viral infection of pigs is one of the bottlenecks restricting the development of the pig industry globally
It is reported that porcine reproductive and respiratory syndrome virus (PRRSV) evades the host immune response by glycosylation modification of its envelope proteins [6], and PEDV evades the host innate immune response by encoding interferon (IFN) antagonists to disrupt the innate immune pathway and hide its viral RNA to avoid exposure of viral RNA to immune sensors [7]
Cecropin P1 (CP1) inhibits the synthesis of RNA and protein and the the results proved that CP1 potently prevents the replication of PRRSV at multiple points in release of virus particles in Marc-145 cells; on the other hand, it weakens the apoptosis induced by the viral life cycle
Summary
Guihong Pen 1,2 , Na Yang 1,2, *, Da Teng 1,2 , Ruoyu Mao 1,2 , Ya Hao 1,2 and Jianhua Wang 1,2, *. Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing 100081, China. Received: 13 October 2020; Accepted: 2 November 2020; Published: 12 November 2020
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