A Review on the Concept of Superfluity Mechanism in Solubility Enhancement

Abstract

Superfluity drug delivery system (SFDDS) is an auspicious conception to obtain adequate oral bioavailability of poorly soluble drugs especially those drugs which are belongs to Biopharmaceutical Classification System II. The drug is in the form of high energy or otherwise swiftly dissolving form such that generated the drug in intraluminal concentrations above the saturation solubility which is liable for desired pharmacological response to the systemic circulation due to superfluity mechanism. The mechanism is based upon spring-parachute and hang-glider effect which involves the inhibition of nucleation with the help of precipitation inhibitors which will act as parachute and glider effect in superfluity formulations and the spring and hang will act as technology used to formulated the dosage form such as amorphous solid dispersion, co-crystals, supersaturated self-emulsifying drug-delivery system correlating to want the biological response is inadequate in the aqueous solubility of drug encountered with formulation development of new drug and existing drug as well as for the new formulation development of existing drug. The methods related to solubilization process are not necessarily improving the absorption in GIT i.e., the free fraction of drug molecules in the inter-micellar phase is limited at the time of dissolution process of the intestinal barrier. This review articles belongs to mechanism of superfluity strategy which overcomes many of the obstacles and limitations of solubilization methods especially very poorly water-soluble drug.