A Review on the Application of RNA based Nanotechnology in In Vivo Computation

Harishchander Anandaram

doi:10.4172/2572-0813.1000117

Abstract

Computing in molecular-scale has been explored from the era of pre genomics with a limitation in Moore's law for devices based on silicon. The development of in vivo computation requires low energy consumption in molecularscale. The concept of DNA computing has rationalized the basic Boolean functions into multi-layered circuits. In the Recent year, the concept of RNA nanotechnology has emerged as an alternative approach because the RNA nanoparticles are emerging as a promising medium for a nanodevice with a platform for computing in molecularscale. In RNA computing, the varieties of small RNA sequences can work antagonistically to carry out computational logic in circuits to execute the process of in vivo computation. Though RNA computation is promising in most cases, but it is still in the infant stage and there are many challenges to collaborations between the people in RNA nanotechnology and computer science to carry out the necessary advancement in performing in vivo computation by RNA Nanotechnology.

Highlights

In order to solve the large requirement of processor development, the concept of “molecular scale computing” was evolved
Apart from the process of computation, the central processing systems with an integrated circuit comprises the implication of logic gates to perform the operations of Boolean logic by receiving the true (i.e., 1 for high voltage) and false (i.e., 0 foe low voltage) values resulting in output
There are more limitations in the application of DNA-based computation in molecular scale computing and the most obvious condition is the intolerable level of execution time in performing the “AND” or “OR” logic because the common execution time is 1–2 h but the application of three-layer see-saw circuits in DNA based molecular scale computing require more than 6–10 h to reach a stable state to achieve the final value

Summary

Introduction

In case of embedded systems and silicon-based computers, circuits with nano chip had become a vital aspect in our life [1] and there is a larger requirement for the development of nano processors to develop a proper protocol for performing computation in various levels of communication. Apart from the process of computation, the central processing systems with an integrated circuit comprises the implication of logic gates to perform the operations of Boolean logic by receiving the true (i.e., 1 for high voltage) and false (i.e., 0 foe low voltage) values resulting in output.

Results

Conclusion