A Review on Orodispersible Tablet by Using Hibiscus rosa sinesis as Natural Superdisintegrant

Abstract

Oral delivery is current standard in the pharmaceutical industry wherever it is regarded as the safest, most suitable and most economical method of drug delivery. The oral cavity is an attractive site for the administration of drugs because of ease of administration. Oro-dispersible drug delivery system are Novel Drug Delivery techniques that make the tablets disintegrate in the mouth without chewing and water, and immediate release and enhanced bioavailability, with better patient compliance. Orodispersible tablets (ODTs), also known as fast melt, quick melts, fast disintegrating have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. Recently, the European Pharmacopeia adopted the term Orodispersible tablet for a tablet that disperses or disintegrates within a minute or second in the mouth before swallowing. Natural polymers remain attractive primarily because they are natural products of plants, readily available, inexpensive, and capable of multitude of chemical modification. Leaves of Hibiscus rosa sinensis Linn (Family: Malvaceae) contains high proportion of mucilage which can be used as additives in pharmaceutical formulations. The investigation of polysaccharides isolated from leaves of Hibiscus rosa sinensis Linn mucilage as a superdisintegrant in the formulation development of Orodispersible Tablets.