Abstract
Microfluidic devices have attracted increasing attention in the fields of biomedical diagnostics, food safety control, environmental protection, and animal epidemic prevention. Micromixing has a considerable impact on the efficiency and sensitivity of microfluidic devices. This work reviews recent advances on the passive and active micromixers for the development of various microfluidic chips. Recently reported active micromixers driven by pressure fields, electrical fields, sound fields, magnetic fields, and thermal fields, etc. and passive micromixers, which owned two-dimensional obstacles, unbalanced collisions, spiral and convergence-divergence structures or three-dimensional lamination and spiral structures, were summarized and discussed. The future trends for micromixers to combine with 3D printing and paper channel were brought forth as well.
Highlights
In the past decade, various microfluidic or lab-on-a-chip [1] devices have been attempted the analysis of biological and chemical targets in the fields of biomedical diagnostics, food safety control, environmental protection, and animal epidemic prevention, etc., and have received increasing attention due to their compact size, automatic operation, faster detection, less reagent, higher sensitivity and in-field use
1 Mixing Index calculated based on Equation (1). 2 Mixing Index calculated based on Equation (2). 3 Mixing Index calculated based on Equation (3). 4 Mixing Index calculated based on Equation (4)
Compared with conventional macro-scale mixers, both passive and active micromixers have demonstrated their features of faster mixing, easier fabrication, higher efficiency, and lower cost
Summary
Various microfluidic or lab-on-a-chip [1] devices have been attempted the analysis of biological and chemical targets in the fields of biomedical diagnostics, food safety control, environmental protection, and animal epidemic prevention, etc., and have received increasing attention due to their compact size, automatic operation, faster detection, less reagent, higher sensitivity and in-field use They can generally integrate injection, mixing, reaction, washing, separation and detection onto a centimeter-level chip [2]. An improved mixing index [4] based on the comparison of the standard deviation to the mean concentration/intensity was reported and could be expressed by MI = 1 −. The advances on both active and passive micromixers over the past five years were reviewed in this study
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