Abstract
Background:COVID-19 remains an emerging pandemic that continuously poses an alarming threat and challenge to economic, social and well-being of the people throughout the world. It also remains an evolving disease which complete pathogenesis that translates into clinical features is only just emerging by each second of the day. There have been observations about the emerging trends of the disease in Nigeria like in any other country in the world where there is outbreak. This study examined from evidence-based literature the emerging pathogenesis of COVID-19 and important points of concern of the disease in Nigeria.Materials and Methods:The paper reviewed published articles in PubMed and Google Scholar using search terms ‘COVID-19” and “SARS-CoV-2”, as well as searched for general COVID-19 information on internet.Results:The result summarized literature on emerging pathogenesis of COVID-19 and important points of concern as well as research questions as to the peculiar trends of the disease in Nigeria.Conclusion:Pathogenesis of COVID-19 remains an emerging knowledge and there are many important research questions that need to be scientifically answered for a successful containment of COVID-19 in Nigeria. It is recommended that all members of intellectual research communities should join the fight against COVID-19 pandemic.
Highlights
Coronavirus disease 2019 (COVID-19) remains a novel and ongoing evolving pandemic that poses unprecedented enormous threat and challenge to the economic, social, and health of humanity all over the regions of the world, with approved vaccines currently available but specific definitive therapy still remain elusive (Zheng, 2020)
The economic constrain of COVID-19 pandemic on global scale according to the preliminary report by United Nations Conference on Trade and Development Agency (UNCTAD) was 2 trillion Dollar as of 9 March 2020, it was estimated that it could reach a projection of 10 trillion Dollar which is about one-eighth of global growth domestic product (GDP) with a palpable potential global economic recession threat (Reuters, 2020)
On 11th February, 2020, the new coronavirus was officially renamed from 2019-nCoV to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Coronavirus Study Group (CSG) of International Committee on Taxonomy of Viruses (ICTV), and on the same date the World Health Organization (WHO) formally termed the disease caused by Severe Acute Respiratory Syndrome (SARS)-CoV-2 as “coronavirus disease 2019”
Summary
Coronavirus disease 2019 (COVID-19) remains a novel and ongoing evolving pandemic that poses unprecedented enormous threat and challenge to the economic, social, and health of humanity all over the regions of the world, with approved vaccines currently available but specific definitive therapy still remain elusive (Zheng, 2020). A new coronavirus was subsequently identified, isolated and reported on 31st December 2019 from the respiratory epithelium of the patients, and was tentatively named initially by China‟s National Health Commission as “2019-novel coronavirus” (2019-nCoV) on 7th January 2020 with the term novel denoting that the virus is only emerging and requires further extensive studies. The first confirmed case of COVID-19 in the United State (US), the current global epicenter of the disease was on January 20, 2020, but in 10 weeks into the period of outbreak (30th March 2020) the number of confirmed cases in US according Johns Hopkins University data was 161,807 cases and 2,978 deaths. This paper discussed emerging pathogenesis of COVID-19 infection and important points of concern as well as research questions pertaining to the peculiar trends of the disease in Nigeria
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