A Review on Drug Penetration Enhancer

Abstract

Drug penetration induced by penetration enhancers has been widely used in dermatological drug delivery, such as treatment of skin carcinoma, anti angina drug delivery and similar therapies. Absorption rate depends on different factors such as hydrophobicity of skin, skin moisture content, molecular size of Drug, pore size and drug penetration. The poor penetration of many drugs with topical application is limited and restrains the optimum drug release into blood stream, which could restrict desired outcomes. Treatment of skin with chemical and physical methods helps in enhancing skin penetration. Chemical methods include modification in formulation, alternative enhancers, blood flow enhancers etc. Physical methods include skin hydration, drug diffusion, iontophoresis and thermal alteration. This review was focused to all the latest issues related to skin penetration enhancers and their use in drug therapy. Also focus on advantages, and drawbacks of drug penetration on human skin. The objective of this review is to evaluate and summarize all recent studies done in the deild of drug penetration enhancers.