Abstract
Chronic non-healing ulcers present a significant clinical challenge due to their prolonged healing times and resistance to conventional treatments. Recent advances in regenerative medicine have introduced autologous platelet-rich plasma (PRP) as a promising therapeutic option. PRP, known for its high concentration of growth factors, has been shown to accelerate wound healing by enhancing tissue regeneration and angiogenesis. When combined with split-thickness skin grafting (STSG), PRP offers a synergistic approach to the management of chronic ulcers. This review evaluates the efficacy of PRP in conjunction with STSG in the treatment of chronic non-healing ulcers, drawing on recent clinical studies, case reports, and trials. The review highlights the biological mechanisms of PRP in wound healing, the procedural considerations in integrating PRP with STSG, and the clinical outcomes associated with this combined approach. Findings suggest that the use of autologous PRP alongside STSG significantly improves graft acceptance, reduces healing time, and promotes faster epithelialization, ultimately leading to better wound closure and patient recovery. However, the need for standardized protocols and further large-scale studies is emphasized to establish consistent guidelines for its use in clinical practice. This review aims to provide healthcare professionals with an updated perspective on this evolving treatment modality for chronic non-healing ulcers. KEY WORDS: Chronic ulcers, Platelet-rich plasma, Split-thickness skin grafting, Regenerative medicine, Wound healing, Tissue regeneration.
Published Version
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