A REVIEW ON ADVANCES OF SUSTAINED RELEASE DRUG DELIVERY SYSTEM

Abstract

Sustained release matrix tablets facilitate prolonged and cont inuous drug release and improve the b ioavailability of drugs while avoiding unwanted side effects. Ofloxacin is a broad spectrum antibacterial agent used for treating wide range of gram positive and gram negative in fections. The goal in designing sustained or controlled delivery systems is to reduce frequency of dosing or to increase the effectiveness of the drug by localization at the site of action, reducing the dose required, providing uniform drug delivery. Sustained release drug administration means not only prolongatio n of duration of dr ug delivery, but the term also implies the predictability and reproducibility of drug release kinetics. The controlled release of drug sub stances and their effective transport to sites of action can be exploited to maximize the beneficial clinical response and to minimize the incidence of unbeneficial adverse reactions and side effects. Oral ingestion has long been the most convenient and commonly employed route of drug delivery. Indeed, for sustained release systems, oral route of administration has receiv ed most of the attention with respect to research on physiological and drug constraints as well as design and testing of prod ucts.