Gastro Retentive ( Floating) Delivery System

Abstract

Because of its flexibility in formulation, ease of administration, and patient compliance, the oral route of drug administration is the most preferred route. However, this route has some limitations, such as a limited gastric residence time (GRT) for sustained drug delivery systems and drugs that are absorbed from a specific region of the gastrointestinal tract (GIT). To overcome these limitations, various approaches to increasing the gastric retention time of the delivery system in the upper gastrointestinal tract have been proposed. The gastroretentive dosage form (GRDF) extends the GRT by directing drug release to the upper part of the GIT. GRDFs enable continuous and prolonged drug release and improve bioavailability of drugs with a narrow therapeutic window, thereby extending dosing intervals and increasing patient compliance. This article's goal is to compile the various gastroretentive approaches. We have summarized important factors controlling gastric retention in order to understand the various physiological difficulties in achieving gastric retention. Finally, the parameters for evaluating gastroretentive drug delivery systems are discussed. The current review briefly discusses the current state of various leading Until now, gastroretentive drug delivery technologies such as high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel, magnetic systems, and so on have been developed. Furthermore, important factors controlling gastroretention, benefits, and future potential are discussed.