A review of Takotsubo (broken-heart) syndrome

Abstract

Background/aims Approximately 2500 people each year in the UK are affected by Takotsubo syndrome. The syndrome is linked to stress and has a higher incidence in women. With a growing population, the number of cases is set to rise. This article examines risk factors and possible causes of Takotsubo syndrome, such as transient ischaemia, catecholamine levels, oestrogen levels and coronary artery spasm. Issues around accurate diagnosis and treatment options are also discussed. Methods A literature review was carried out using online databases such as CINAHL and BNI, incorporating international journals from the year 2000 onwards, to give a broad spectrum of information. Results It is clear from the literature review that Takotsubo syndrome is still widely misunderstood, which can lead to misdiagnosis and incorrect treatment. There are many theories as to the cause of Takotsubo syndrome, but no definitive answer. Conclusions Further research around Takotsubo syndrome is needed to minimise misdiagnosis. Further studies into ECG and troponin changes associated with Takotsubo syndrome may make it possible for Takotsubo syndrome to be diagnosed on admission and not mistaken for acute coronary syndrome.