A Review of Kinetics of Nanoparticulated Delayed Release Formulations

Abstract

The history and development of chemical kinetics gives a fascinating insight into the way in which theory and experiment can become mutually interdependent. Kinetics plays a key role in the study of what the body dose to a drug so these areas of study move towards pharmacokinetics. In the last decade or so there has been a vast upsurge of interest in the physical mechanism of reaction. The United States Pharmacopeia (USP) defines delayed-release tablets as enteric-coated to delay release of the medication until the tablet has passed through the stomach. To prevent the drug from being destroy or inactivate by gastric juices or where it may irritate the gastric mucosa. The suitability of several equations which have been reported in the literature to define drug release mechanism was tested with respect to the release data. To analyze the mechanism of drug release from the matrix tablet data obtained from the drug release studies were analyzed according to zero order model, Higuchi model, and Korsmeyer - Peppas model respectively