Abstract
The utilization of natural gum polysaccharides as the vehicle for drug delivery systems and other biomedical applications has increased in recent decades. Their biocompatibility, biodegradability, and price are much cheaper than other materials. It is also renewable and available in massive amounts, which are the main reasons for its use in pharmaceutical applications. Gum can be easily functionalized with other natural polymers to enhance their applications. Various aspects of the utilization of natural gums in the forms of polyelectrolyte complexes (PECs) for drug delivery systems are discussed in this review. The application of different mathematical models were used to represent the drug release mechanisms from PECs; these models include a zero-order equation, first-order equation, Higuchi, simplified Higuchi, Korsmeyer–Peppas, and Peppas–Sahlin.
Highlights
With the increasing concentration (2–10% w/w), pure xanthan gum solution showed higher G0 than G”; this behavior shows the reinforcement of chitosan and xanthan in the polyelectrolyte complexes (PECs) network formation depend on the drying methods [26]
This study presents the possibility of photocrosslinkable Methacrylated gellan gum (MeGG) tuning the physicochemical and mechanical characteristics for broad application of tissue engineering such as bone, skeletal, and cardiac muscle to neural tissue
Natural gums are widely applied in food formulation and pharmaceutical applications
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. The most common hydrocolloid polysaccharides used in the food industry are gum, alginate, carboxymethyl cellulose. Most polysaccharides have an anionic or neutral charge by nature, but chitosan has a positive charge due to its amino functional group. The combination of natural polymer hydrocolloid, gum and chitosan are the general examples of most research studies of polyelectrolyte complexes (PEC) as a pharmaceutical excipient [8]. When cationic and anionic polymers are mixed, they form a random bond This step is called primary complex formation. The structure produced from the electrostatic attractions is influencedthe by ratio of cationic and anionic functional of the ratio of cationic and anionic functionalgroups, groups,which whichdetermine determinethe the characteristics characteristics of PEC, whether it is soluble or insoluble [14].
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