Abstract
AbstractThis contribution reviews polyelectrolyte (PEL) complex (PEC) nanoparticles prepared by mixing solutions of oppositely charged PELs, with special focus on the regulation of their size and shape by PEL structural and media parameters and on their pharmaceutical applications. Experimental and simulation evidence indicates that salt and PEL concentration, pH, mixing ratio and order, PEL molecular weight and topology are useful parameters for regulation of the size and internal structure of spherical PEC nanoparticles. Experimental and theoretical data are presented to show that PEL flexibility and stiffness are able to influence and even control PEC nanoparticle shape. Finally, the options, advantages, and challenges of dispersed PEC particles for pharmaceutical applications are outlined, emphasizing the uptake and release properties towards proteins and drugs and the interaction of these nanoparticles with cells.KeywordsCoacervateNanoparticlesPolyelectrolyte cell interactionPolyelectrolyte complexesPolyelectrolyte drug interaction
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