Abstract
The fruits of Ziziphus jujuba, commonly known as jujube, red date or Chinese date, are taken as fresh or dried food, and as traditional medicine worldwide due to high nutritional and health values. Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. Thus, the blood-nourishing function of jujube is being proposed here. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia.
Highlights
Jujube is usually called red date or Chinese date, which is the fruit of Ziziphus jujuba Mill. that belongs to Rhamnaceae family
The activities of dietary jujube on the levels of red blood cells (RBCs), hemoglobin and hematocrit were analyzed in colitis-associated colon cancer mice. These hematopoietic parameters in cancer mice were significantly decreased, as compared to control group; which were markedly increased in the jujube-treated mice (Periasamy et al, 2020), suggesting possible beneficial effects of this fruit on cancer patients suffering from anemia
In pARE-Luc-expressed cells treated with jujube water extract, the luciferase assay was activated in a dose-dependent manner (Chen J. et al, 2016)
Summary
Jujube is usually called red date or Chinese date, which is the fruit of Ziziphus jujuba Mill. that belongs to Rhamnaceae family. Jujube extract regulated pro-inflammatory cytokine expressions under different conditions via NF-kB signaling Ju-B-2 from jujube induced spleen cells proliferation, and the structural-activity relationship of which in stimulating immune response were proposed These hematopoietic parameters in cancer mice were significantly decreased, as compared to control group; which were markedly increased in the jujube-treated mice (Periasamy et al, 2020), suggesting possible beneficial effects of this fruit on cancer patients suffering from anemia.
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