Abstract
Artemisinin is a sesquiterpene lactone isolated from the aerial part of sweet wormwood (Artemisia annua L.) in the 1970s. Based on its derivatives, the most effective medicines for the treatment of malaria have been created and are widely used. Over the past two decades, numerous in vitro and in vivo studies have been performed. They have shown the anticancer activity of these drugs in relation to certain cancer cell lines.The aimof the study is the review the scientific information on the clinical cases and the results of clinical trials carried out using drugs based on artemisinin derivatives. Material and methods.The study was conducted with the use of information search (PubMed, ScholarGoogle,) and library databases (Cochrane, eLibrary, Cyberleninca), as well as ResearchGate application for semantic search.Results and discussion. It has been established that the largest number of known clinical cases and completed clinical studies is associated with the study of the anticancer activity of one of the artemisinin derivatives - artesunate. The data obtained by various research groups do not yet allow us to speak of a pronounced activity of the latter. However, the facts of prolonging the life of patients, improving its quality, increasing control over the disease have been established.Conclusion. The published data of clinical cases and clinical studies performed for the period from 2001 to 2016, instill restrained optimism about the prospect of using drugs based on some artemisinin derivatives in oncology.
Highlights
Cancer is the leading cause of death globally. 9.6 million deaths from this disease are expected in 2018
He decrease of the tumor marker and the regression of tumor as analyzed by magnetic resonance tomography (MRT) was observed upon Artemisia annua treatment followed by a several months
Over the past two decades, a num ber of clinical cases have been described and clinical stud ies have been carried out on artemisinin derivatives used in the treatment of patients with various types of cancer
Summary
Artemisinin is a sesquiterpene lactone isolatedfrom the aerial part o f sweet wormwood (Artemisia annua L.) in the 1970s. Результаты показывают, что непре [32,33,34] рывное потребление артесуната в течение 4 недель в дозах до 200 мг (2,2-3,9 мг/кг) в день хорошо пере носилось и было безопасно. Авторы исследования сделали вывод, что артесунат может использоваться для лече ния немелкоклеточного рака легкого. Исследование Th. Ericsson и его коллег [31] своей целью определяло возможность охарактеризовать по пуляционную фармакокинетику артесуната (по про дукту его метаболизма - дигидроартемизинину) во время длительного лечения пациентов с метастатиче ским раком молочной железы и оценить потенциаль ную зависимость фармакокинетических параметров от времени. Снижение показателя ПСА и регрессия опухоли, как было установлено с помощью магнит но-резонансной томографии, наблюдались в процессе лечения, а затем ещё в течение нескольких месяцев. Комбинационная терапия с использованием из вестных химиотерапевтических средств в сочетании с некоторыми производными артемизинина, может способствовать разработке более эффективной, ме нее токсичной и недорогой химиотерапии некоторых онкологических заболеваний
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