Abstract

Auraptene is a bioactive monoterpene coumarin isolated from Citrus aurantium and Aegle marmelos that belong to the Rutaceae family. Auraptene can modulate intracellular signaling pathways that control cell growth, inflammation and apoptosis and can exert pharmacological properties such as anti-bacterial, anti-fungal, antileishmania and anti-oxidant activity. Auraptene had inhibitory and chemo-preventive effects on the proliferation, tumorigenesis and growth of several cancer cell lines through increase in the activity of glutathione S-transferase, formation of DNA adducts and reduction of the number of aberrant crypt foci. Auraptene exhibits anticancer effects via targeting different cell signaling pathways such as cytokines, genes modulating cellular proliferation, growth factors, transcription factors and apoptosis. The present review is a detailed survey of scientific researches on the cytotoxicity and anticancer activity of Auraptene on cancer cells and tumor bearing animals.

Highlights

  • Coumarins are a large class of natural compounds mainly found in the Apiaceae, Rutaceae, and Composita families

  • 7-geranyloxycoumarin, is a member of umbelliferone coumarins in which the phenolic hydrogen has been replaced by a geranyl group

  • Auraptene has been reported to prevent the proliferation of colorectal cancer by modulation of inflammatory and expression of proinflammatory cytokines in CD-1 (ICR) mice. These results indicate that the administration of auraptene suppresses the colonic inflammation and modulates proinflammatory cytokines including interleukin (IL)-6 and IL-1b, tumor necrosis factor-a, nuclear factor-kappaB, Stat3 and NF-E2-related factor 2 in adenocarcinomas (Tanaka et al, 2010)

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Summary

A Review of Auraptene as an Anticancer Agent

Specialty section: This article was submitted to Pharmacology of Anti-Cancer Drugs, a section of the journal Frontiers in Pharmacology. Auraptene is a bioactive monoterpene coumarin isolated from Citrus aurantium and Aegle marmelos that belong to the Rutaceae family. Auraptene can modulate intracellular signaling pathways that control cell growth, inflammation and apoptosis and can exert pharmacological properties such as anti-bacterial, anti-fungal, antileishmania and antioxidant activity. Auraptene had inhibitory and chemo-preventive effects on the proliferation, tumorigenesis and growth of several cancer cell lines through increase in the activity of glutathione S-transferase, formation of DNA adducts and reduction of the number of aberrant crypt foci. Auraptene exhibits anticancer effects via targeting different cell signaling pathways such as cytokines, genes modulating cellular proliferation, growth factors, transcription factors and apoptosis. The present review is a detailed survey of scientific researches on the cytotoxicity and anticancer activity of Auraptene on cancer cells and tumor bearing animals

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