Abstract
The oral route of drug administration is the most important method for administering drugs for systemic effects. The oral drug delivery market, in particular, remains the largest segment of the overall drug delivery market, presently valued at $49 billion, and growing at a rate of 10% each year 1 . Except in certain cases the parenteral route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects. So therefore fast dissolving drug delivery has received ever-increasing demand during last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the saliva without need of water with good mouth feel property. The popularity and usefulness of the formulation resulted in development of several FDT technologies. Fast- or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. This review explains the recent advances in fast dissolving drug delivery systems with special focus on its new breakthrough in various formulation aspects resulted in development of several FDT technologies
Highlights
Recent advances in Novel Drug Delivery System (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance
Sometimes it may be difficult to swallow conventional products due to unavailability of water[8]. These problems led to the development of novel type of solid oral dosage form called “Mouth Dissolving Tablets”
Definition United States Food and drug administration (FDA) defined fast dissolving tablet (FDT) as “a solid dosage form containing medicinal substance or active ingredient which disintegrate rapidly usually within a matter of seconds when placed upon the tongue[11].Fast dissolving tablets are known as mouthdissolving tablets, melt-in mouth tablets, Orodispersible tablets, rapidmelts, porous tablets, quick dissolving tablet
Summary
Recent advances in Novel Drug Delivery System (NDDS) aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance. Sometimes it may be difficult to swallow conventional products due to unavailability of water[8] These problems led to the development of novel type of solid oral dosage form called “Mouth Dissolving Tablets”. The risk of chocking or suffocation during oral administration of conventional formulation due to physical obstruction is avoided, providing improved safety Beneficial in cases such as motion sickness, sudden episodes of allergic attack or coughing, where an ultra rapid onset of action required. Have one drawback that it is hygroscopic not used with moisture sensitive drugs This superdisintegrants act by swelling and due to swelling pressure exerted in the outer direction or radial direction, it causes tablet to burst or the accelerated absorption of water leading to an enormous increase in the volume of granules to promote disintegration. Figure.[1].Mechanism of superdisintegrants by swelling
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