Abstract
Despite its short length, the anal canal is an anatomically and histologically complex organ that can harbor many benign and malignant conditions. The trend for anal cancer has been on the rise, affecting predominantly women. In recent years, new concepts have emerged regarding anal tumor origin, pathogenesis, classification, and molecular characterization. Particularly, the role of human papillomavirus (HPV) has been increasingly recognized for its important role in anal carcinogenesis, not just for squamous lesions, but also for non-squamous neoplasia. Understanding different mechanisms of tumorigenesis are essential for proper tumor classification, which will allow more accurate diagnosis, proper clinical management, and optimal patient outcomes. This review aims to provide an overview of the normal anatomy, histogenesis, and pathogenesis of the anal canal, as well as to update on current knowledge of epithelial tumors associated with HPV.
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