Abstract
Small interfering RNAs (siRNAs) are short (19-29bp) double stranded nucleic acids that efficiently mediate gene silencing in mammalian cells by directing the degradation of complementary target mRNA sequences. This has justified the recent development of technologies for siRNA transport into a host cell. Synthetic cationic lipid (CL) assemblies can efficiently be used to deliver siRNA, leading to highly specific gene silencing [1].
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