A reëvaluation of sulfonamide therapy.

Abstract

Article1 August 1955A REËVALUATION OF SULFONAMIDE THERAPYELLARD M. YOW, M.D.ELLARD M. YOW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-2-323 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is not difficult to understand the decreased interest in the sulfonamides following the introduction of penicillin, an agent which produced dramatic therapeutic results and which could be administered in unlimited amounts without evidence of toxicity. This came as an impressive relief after the trying years of carefully regulating the dose of the sulfonamides so as to maintain an effective level and yet remain within the relatively narrow margin between the toxic and therapeutic levels. Physicians were anxious to forget the difficulties encountered in the administration of large amounts of fluid and alkali, given in an attempt to prevent the...Bibliography1. Von Oettingen WF: Untoward effects resulting from the indiscriminate use of antibiotics: an appraisal of the literature, Antibiotics Annual, 1954-1955, pp. 361-378. Google Scholar2. RoblinWilliamsWinnekEnglish ROJHPSJP: Chemotherapy. II. Some sulfanilamido heterocycles, J. Am. Chem. Soc. 62: 2002-2005 (Aug.) 1940. CrossrefGoogle Scholar3. GoodmanGilman LA: The pharmacological basis of therapeutics, 2nd Ed., 1955, The Macmillan Co., New York, pp. 1276-1320. Google Scholar4. Lehr D: Inhibition of drug precipitation in the urinary tract by the use of sulfonamide mixture. I. Sulfathiazole-sulfadiazine mixture, Proc. Soc. Exper. Biol. and Med. 58: 11 (Jan.) 1940. CrossrefGoogle Scholar5. LehrTerranovaBlumenfeldGoldfarb DRSML: Therapy with a new sulfonamide triple mixture: sulfadiazine-sulfamerazine-Elkosin, Postgrad. Med. 13: 231-238, 1953. CrossrefMedlineGoogle Scholar6. SarnoffFreedmanHyman SJMAAA: The treatment of Bacillus proteus infections with NU-445, J. Urol. 55: 417-427, 1946. CrossrefMedlineGoogle Scholar7. Siniscal AA: The sulfonamide and antibiotics in trachoma, J. A. M. A. 148: 637-639 (Feb. 23) 1952. CrossrefMedlineGoogle Scholar8. Rantz LA: The streptococcal etiology of rheumatic fever, M. Clin. North America 39: 339-351 (Mar.) 1955. CrossrefGoogle Scholar9. Yow EM: Observation on the use of sulfisoxazole in 1000 consecutive patients, with particular reference to the frequency of undesirable side effects, Am. Pract. and Digest. Treat. 4: 521-525 (Aug.) 1953. MedlineGoogle Scholar10. WeinsteinGoldfieldChang LMT: Infections occurring during chemotherapy, New England J. Med. 251: 247-255 (Aug. 12) 1954. CrossrefMedlineGoogle Scholar11. KutscherLaneSegall AHSLR: The clinical toxicity of antibiotics and sulfonamides, J. Allergy 25: 135-150 (July) 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Houston, Texas*From the Symposium on Infection, presented at the Thirty-sixth Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 29, 1955.From the Department of Medicine, Baylor University College of Medicine, and the Jefferson Davis Hospital, Houston, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBritish blood cholesterol values and the American consensus.Co-trimoxazole toxicity.Sulfonamides and SulfonesSulfonamide (Sulfanilamide; SA)Antibacterial Chemotherapy with SulfonamidesThe SulfonamidesThe Use of Sulfadimethoxine in the Treatment of Urinary Tract InfectionsDrug allergy in pediatric practiceSULFADIMETHOXINE IN URINARY TRACT INFECTIONS*SEVERE TOXIC REACTIONS ASSOCIATED WITH SULFAMETHOXYPYRIDAZINE (KYNEX)*J. SALVAGGIO, M.D., F. GONZALEZ, M.D.Prolonged Treatment of Urinary-Tract Infections with SulfamethoxypyridazineCLINICAL USE OF A LIPID EMULSION OF SULFISOXAZOLETHERAPY IN COLLAPSE DUE TO MENINGOCOCCUS INFECTION*JAMES E. CASSIDYSULFISOXAZOLE (GANTRISIN): CONCENTRATION IN PLASMA AND DIFFUSION INTO THE CEREBROSPINAL FLUID†The Newer SulfonamidesEvaluation of sulfaethylthiadiazole (SETD) in common infectious states in childrenThe Medical Management of Urinary Tract InfectionsSome Abuses of Drugs in Therapy 1 August 1955Volume 43, Issue 2Page: 323-332KeywordsHospital medicineMeningococcal diseasePenicillinPneumoniaStaphylococcal infectionStaphylococcusSulfonamideToxicityUpper respiratory tract infectionsUrinary tract infections ePublished: 1 December 2008 Issue Published: 1 August 1955 PDF downloadLoading ...