Abstract
Background: Urinary tract infections (UTIs) are one of the most common infections encountered in clinical practice. Objective: This is a retrospective study to evaluate the antimicrobial susceptibility pattern of aerobic microbial isolates from urine samples of patients with complaints suggestive of UTI. Materials and methods: A total of 3116 urine samples which were received in the Department of Microbiology during the study period from April 2018 to March 2019 were analyzed. Results: Out of 3116 urine samples from both outpatient (OPD) and inpatient department (IPD), 2614 samples showed either growth of contaminants or insignificant or no growth of microorganisms, whereas, 502 samples showed significant microbial growth on aerobic culture giving overall prevalence of UTI in the study population to be 16.1%. Of these 502 culture positives, majority was found to be from OPD (51.0%) patients, amongst females (62.9%), and Escherichia coli being the commonest isolate (49.8%). The antibiotic sensitivity of uroisolates of Escherichia coli were found to range from 46.0-70.0%. Conclusion: In view of the increasing drug resistance amongst pathogens causing UTI, antimicrobial susceptibility should be done before initiating definitive therapy. These data may be used to formulate local antibiotic policies in order to assist clinicians in the rationale use of antibiotics.
Highlights
A urinary tract infection (UTI) is an infection in any part of urinary tract comprising of kidneys, ureters, bladder and urethra
Out of 3116 urine samples from both outpatient (OPD) and inpatient department (IPD), 2614 samples showed either growth of contaminants or insignificant or no growth of microorganisms, whereas, 502 samples showed significant microbial growth on aerobic culture giving overall prevalence of UTI in the study population to be 16.1%. Of these 502 culture positives, majority was found to be from OPD (51.0%) patients, amongst females (62.9%), and Escherichia coli being the commonest isolate (49.8%)
In view of the increasing drug resistance amongst pathogens causing UTI, antimicrobial susceptibility should be done before initiating definitive therapy
Summary
A urinary tract infection (UTI) is an infection in any part of urinary tract comprising of kidneys, ureters, bladder and urethra. The lower urinary tract i.e. the bladder and the urethra are often involved. UTIs are caused by bacteria, fungi and rarely by viruses. Females suffer from UTI more often than the males because of the shortness of urethra and its anal proximity. Risk factors include immune suppression, trauma, foreign body, broad spectrum antibiotic use, infused body fluids like saline irrigations and urinary catheterization. Escherichia coli from the gut is the cause of 80 – 85% UTIs, followed by Klebsiella, Proteus, Pseudomonas and Citrobacter [1, 2]. Urinary tract infections (UTIs) are one of the most common infections encountered in clinical practice.
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