Abstract
Introduction: Urinary tract infection (UTI) is one of the most prevalent diseases affecting people of all age groups i.e. from neonate to geriatric age group. Widespread use of antibiotics has led to the emergence of resistant microorganisms. As the antibiogram of the microorganisms are frequently changing hence the present study was done to analyze the recent antibiotic sensitivity pattern of uropathogens in urinary tract infection. Materials and Methods: In present study is a retrospective analysis of culture results of urine samples, was conducted at Microbiology department of tertiary health care hospital in Mumbai. The age & sex of patients, the organism isolated and also the antimicrobial susceptibility profiles were collected from the laboratory registers using a standard data collection form. Results: The overall prevalence of UTI was 33.54% of which 66.78% were females and 33.22% were from males. High prevalence was observed in females as compared to males (2:1). Though the overall prevalence was high in old aged (>45 years) patients, in females high prevalence was seen among middle-aged (31 to 45 years) patients and in male high prevalence was seen among old age (>45 years) patients. From total 584 uropathogens, E.coli (53.77%) was the commonest isolate causing UTI followed by Klebsiella pneumoniae (27.40%). The most effective antimicrobial agents in our study were Meropenem, gentamicin, Nitrofurantoin and Cotrimoxazole whereas higher resistance was observed among Fluoroquinolones, Amoxicillin and third generation Cephalosporins, these are the drugs which are commonly given emperically for UTI. Conclusion: As drug resistance among bacterial pathogens is vary with time to time regular surveillance and monitoring is necessary for giving updated information to physician for most effective empirical treatment of UTIs. Keywords: Urinary tract infection, Prevalence, Antibiotics resistance, Uropathogenes.
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