Abstract
Based on the antibody typing classification, Helicobacter pylori infection can be divided into type I H. pylori infection and type II H. pylori infection. To observe the effects of different H. pylori infection types on the distribution of histopathological characteristics and the levels of three items of serum gastric function (PG I, PG II, G-17). 1175 cases from October 2018 to February 2020 were collected with ratio 1:2. All patients were performed with 14C-Urea breath test (14C-UBT), H. pylori antibody typing classification, three items of serum gastric function detection, painless gastroscopy, pathological examination, etc. According to H. pylori antibody typing classification, patients were divided into three groups: type I H. pylori infection group, type II H. pylori infection group and control group. Significant difference existed among type I H. pylori infection group, type II H. pylori infection group and control group in inflammation and activity (χ2 = 165.43, 354.88, P all < 0.01). The proportion of three groups in OLGA staging had statistic difference (χ2 = 67.99, P all < 0.01); Compared with type II H. pylori infection group and control group, the level of pepsinogen I, pepsinogen II, gastrin17 in type I H. pylori infection group increased, and PG I/PG II ratio (PG I/PG II ratio, PGR) decreased, which was statistically significant (χ2 = 35.08, 166.24, 134.21, 141.19; P all < 0.01). Type I H. pylori infection worsened the severity of gastric mucosal inflammation and activity. H. pylori infection was prone to induce atrophy of gastric mucosa, while type I H. pylori infection played a key role in promoting the progress of atrophic gastritis and affected the level of serum gastric function. The study indicated that the eradication of H. pylori should be treated individually.
Highlights
Helicobacter pylori (H. pylori), a single polar, multiple flagellum and spirally curved gram-negative bacilli belongs to the micro aerobic bacteria, whose main infection site is the stomach and duodenal sphere
Based on H. pylori antibody typing classification, all inpatients were divided into three groups: type I H. pylori infection group, type II H. pylori infection group and control group. 235 inpatients were enrolled in type II H. pylori infection group and the other two groups were 470 inpatients respectively (1:2 paired)
It is a consensus that H. pylori infection is the cause of chronic gastritis, and H. pylori can cause sustained damage to gastric mucosa
Summary
Helicobacter pylori (H. pylori), a single polar, multiple flagellum and spirally curved gram-negative bacilli belongs to the micro aerobic bacteria, whose main infection site is the stomach and duodenal sphere. H. pylori has a significant correlation with chronic gastritis with gastric mucosal atrophy and erosion, peptic ulcer, MALT lymphoma and gastric cancer (GC)[1,2]. About 20% of H. pylori infected patients develop precancerous lesions but only 2% develop gastric cancer, which is closely related to the host genetic, environment and virulent strains of H. pylori[3]. H. pylori has different characteristics of virulence of the infecting strain. A large sample cohort study has shown that H. pylori positive patients experienced chronic gastritis to AG and eventually to intestinal metaplasia, and the risk of gastric cancer is sina.com. This study aims to analyze the relationship between different types of H. pylori infection on the distribution of histopathological characteristics and the levels of three items of serum gastric function. As well as to provide a theoretical basis for the clinical individual eradication of H. pylori and a possible mechanism of type I H. pylori infection in the development of AG
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