A regulatory switch in obesity

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Metabolism The liver not only produces glucose but also consumes a large amount of glucose, making this organ critical for glucose homeostasis. Kokaji et al. performed multiomics analyses on the liver and blood of normal mice and in a genetic mouse model for obesity ( ob/ob ). Whereas normal hepatic metabolic responses to glucose were rapid and relied on regulation by metabolites, those in ob/ob mice were slow and depended on changes in gene expression. Thus, obesity in this model not only slows hepatic metabolic responses to glucose but also makes these responses more energy consuming and less precise. Sci. Signal. 13 , eaaz1236 (2020).