Abstract
We report the fabrication and characterization of an optical fiber biochemical sensing probe based on localized surface plasmon resonance (LSPR) and spectra reflection. Ordered array of gold nanodots was fabricated on the optical fiber end facet using electron-beam lithography (EBL). We experimentally demonstrated for the first time the blue shift of the LSPR scattering spectrum with respected to the LSPR extinction spectrum, which had been predicted theoretically. High sensitivity [195.72 nm/refractive index unit (RIU)] of this sensor for detecting changes in the bulk refractive indices has been demonstrated. The label-free affinity bio-molecules sensing capability has also been demonstrated using biotin and streptavidin as the receptor and the analyte.
Highlights
There is widespread interest in the development of chemical and biochemical sensors based on plasmonic resonance of metallic nanostructures
In our previous publication [15], we have reported high sensitive localized surface plasmon resonance (LSPR) biochemical sensing based on transmission spectra of ordered array of metallic nanodots fabricated on the optical fiber tip using electron beam lithography (EBL)
In this work we report high sensitive LSPR biochemical sensing based on reflection spectra of ordered arrays of metallic nanodots fabricated on the optical fiber tip using electron-beam lithography (EBL)
Summary
There is widespread interest in the development of chemical and biochemical sensors based on plasmonic resonance of metallic nanostructures. The property of spectra position of metallic nanostructure depended on the dielectric environment is widely used as the working principle for the label-free chemical and biological sensing applications [3,4,5,6,7,8,9] These investigations have been on planar substrates such as glass or sapphire substrates. In our previous publication [15], we have reported high sensitive LSPR biochemical sensing based on transmission spectra of ordered array of metallic nanodots fabricated on the optical fiber tip using electron beam lithography (EBL). In this work we report high sensitive LSPR biochemical sensing based on reflection spectra of ordered arrays of metallic nanodots fabricated on the optical fiber tip using EBL. Received 7 Dec 2010; revised 14 Jan 2011; accepted 28 Jan 2011; published 1 Feb 2011 1 March 2011 / Vol 2, No 3 / BIOMEDICAL OPTICS EXPRESS 479
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