Abstract
A redox-neutral nickel-catalysed sulfonylation for arylsulfone synthesis were developed. (Hetero)aryl boronic acids reacted with potassium metabisulfite (K2S2O5) and readily available 2-chlorothiazoles in the presence of air-stable Ni(OTf)2 and 4,4-di-tert-butyl bipyridine (dtbbpy) as a commercially available ligand to produce the corresponding 2-sulfonylthiazoles in moderate to excellent yields. This practical protocol tolerates a wide range of substrates including boronic acids and 2-chloro(benzo)thiazoles without additional bases, allowing the direct synthesis of functional arylsulfones.
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