Abstract
A ratiometric two-photon fluorescent probe (MQ) was designed and synthesized to detect cysteine (Cys) and homocysteine (Hcy) with high selectivity. MQ exhibited a large two-photon absorption cross-section at 710nm (265GM). Significant blue-shifts of both fluorescent and UV–vis spectra of MQ were found upon the addition of Cys or Hcy. MQ responded to Cys/Hcy much faster than previous reported two-photon fluorescent probes for Cys/Hcy. The response mechanism was proved by 1H NMR, Maldi-TOF MS and theoretical calculation. Cell cytotoxicity and bio-imaging studies revealed that MQ was cell-permeable and could be used to detect Cys with low cytotoxicity under two-photon excitation.
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