Abstract
A rate enhancement of tert-butoxycarbonylation of aromatic amines by Boc 2O in alcohols compared to aprotic solvents was demonstrated. Kinetic analysis by NMR suggested that the reaction in CD 3OD was faster than in CDCl 3 by a factor of 70. Reactions between Boc 2O and various aliphatic and aromatic amines in ethanol provided the N-Boc derivatives in good to excellent yields in short reaction times.
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