Abstract
Pulmonary carcinoids are rare pulmonary neoplasms which account for 1-2% of all lung neoplasms. Pulmonary carcinoid tumors are a rare cause of ectopic ACTH secretion. The incidence of Cushing's syndrome in pulmonary carcinoid tumor is approximately 1%. A case of 25-year-old young male with typical cushingoid appearance presented with headache on and off and episodes of hypertension since 1year.Thoracic CT revealed a nodular region in left lower lobe. The patient underwent left lower lobectomy and histopathology revealed an atypical carcinoid tumor. On immunohistochemistry, tumor cells were positive for CK PAN9, CD117, S100, TTF-1, synaptophysin, chromogranin and negative for P40, CK7, Her-2 and CD99.This case is presented for its rarity.
Highlights
Bronchial carcinoids represent small portion of all pulmonary tumors and Carcinoid tumors are the neuroendocrine tumors arising from enterochromaffin cells
The endogenous Cushing syndrome comprises three distinct pathogenic disorders: pituitary, Pulmonary carcinoids are rare pulmonary neoplasms which account for 1-2% of all lung adrenal and ectopic [4]
A whole body Ga-68 DOTANOC PET CT was planned to characterize the lesion as well as to localize metastatic lymph node which revealed centimetric nodular lesion (1.1x0.8cm) with no significant tracer uptake was seen in left lung lower lobe and a possibility of atypical carcinoid/small cell carcinoma was made
Summary
Bronchial carcinoids represent small portion of all pulmonary tumors and Carcinoid tumors are the neuroendocrine tumors arising from enterochromaffin cells They are a rare cause of ectopic ACTH secretion.
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