Abstract
A Rare Case of Merkel Cell Carcinoma Presented with Lambert Eaton Myasthenic Syndrome without Cutaneous Findings
Highlights
Merkel cell carcinoma (MCC) first described in 1972, is a very rare aggressive skin malignancy primarily seen in white men patients above 70 years old [1] and has the propensity for local recurrence and regional lymph node metastases [2,3]
Skin examination of the lower limbs, external genitalia and anus was normal. He had a characteristic neurophysiological examination indicating a presynaptic transmission deficitand subsequently was tested for the presence of voltage-gated calcium channel (VGCC) antibodies, based on the clinical suspicion of having Lambert Eaton Myasthenic Syndrome (LEMS)
LEMS is an uncommon disorder of neuromuscular junction transmission presenting as slowly progressive proximal muscle weakness with the patients describing an alteration in gait or difficulty arising from a chair
Summary
A Rare Case of Merkel Cell Carcinoma Presented with Lambert Eaton Myasthenic Syndrome without Cutaneous Findings. Merkel cell carcinoma (MCC) is a rare cutaneous malignancy that has a propensity for local recurrence and regional lymph node metastases. It presents in older patients with light skin tones as a rapidly growing intracutaneous nodule. Lambert-Eaton myasthenic syndrome (LEMS) is a disorder of neuromuscular junction, where most patients present with complaints of slowly progressive proximal muscle weakness as a paraneoplastic neurologic symptom of small cell carcinoma. We present a case of LEMS that was diagnosed in a patient with MCC. 6 cases developed LEMS on the ground of MCC.
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