Abstract
AbstractWe have developed a solvent‐free phase‐transfer catalysis (PTC) method for the N‐alkylation of sulfur‐substituted dihydropyridone 4a to give products 5 with varying side‐chains and functional groups. Treatment of the chlorides 5a and 5c with NaI in acetone at reflux gave high yields of the iodides 6a and 6b. The reaction of iodides 7a and 7b with t‐BuLi at low temperature, followed by sequential treatment with HOAc and NaBH4, resulted in the formation of quinolizidine 8a and pyridoazepine 8b, respectively. Similar reaction of bromide 5j with t‐BuLi gave indolizidine 11.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
