Abstract
AbstractHauge, J. G. anti R. Nicolaysen. A rapid method for the study of the effect of unsaturated fatty acids on cholesterol metabolism in rats. Acta physiol. scand. 1959. 45. 19–25. – A method for biological testing of the effect of unsaturated fatty acids on the cholesterol metabolism in rats is described. Pregnant mothers and the litters born are given a diet containing 10 % hydrogenated coconut oil and 1 % cholesterol. The young rats grow approximately at a normal rate the first 4 weeks of life; in the following 50 days weight increase slows down and very high liver and plasma cholesterol values result together with various symptoms of essential fatty acid deficiency. Serum cholesterol is analysed in each rat, and grouping follows according to sex and serum cholesterol values so that equal group values result for zero day. Next the fatty acids or fats to be tested are dosed in geometrically increasing doses with 10–12 rats in each group. Following two weeks daily dosing, a new blood sample is collected and the depression of serum cholesterol for each group is calculated. Liver and plasma cholesterol are approximately equally depressed, and group reductions of more than 50 % have been observed.
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